George Adams built this beautifully executed microscope during the 1750s as a tribute to the ascending Prince of Wales. It is regarded by many as the peak of his achievements as a result of the superb craftsmanship and practicality.

Adams used a focus mechanism similar to the design of Cuff, in which sleeves and movable pillars are employed to move the body tube. Changing objective lenses on this microscope was conveniently accomplished by rotating the wheel of objectives that is clearly illustrated in the figure above. The wheel carried objective lenses ranging in focal length between 1/20 and 3/4 inches, similar to those found on Adams' earlier model, the New Universal Double Microscope. Three variations of stage design were incorporated into this microscope. The stage in the illustration was used to constrain small animals, such as amphibians and small rodents, to study the circulation of blood.

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