Picolinic acid is the body's prime natural chelator of the vital trace elements chromium, zinc, manganese, copper, iron, and molybdenum. Biosynthesized in the liver and kidneys from the amino acid tryptophan, and stored in the pancreas during digestion, picolinic acid is secreted into the intestine.

As an isomer of nicotinic acid, picolinic acid is a six-member cyclic compound which has a nitrogen atom in place of one of the carbon ring members, plus a carboxyl side chain. There are 6 carbon, 5 hydrogen, 1 nitrogen, and 2 oxygen atoms per molecule, and the compound's molecular weight is 123.1. Allowed to cool from a melt, slowly-recrystallizing picolinic acid forms beautiful dendritic, needle-like crystals.

In the process of chelation, picolinic acid (PA), known also as 2-pyridine carboxylic acid to biochemists, is able to attract a positively charged ion into its larger molecular structure and shield the charge so that the ion appears to be neutral or negatively charged. The chelated elements are able to pass through the polarized cellular membranes while the free ions are excluded. This chelation of certain trace elements by picolinic acid is thought to make them more readily available to the body as nutrients.

Among the evidence supporting breast-feeding of infants over the feeding of cow's milk or commercial formula is that picolinic acid is found at 30 times the concentration in a mother's milk compared to cow's milk, and about 300 times greater than in infant formula. Even though pasteurized cow's milk has twice as much zinc as mother's milk, much more zinc is absorbed by the baby that is nursing. Without the help of picolinic acid, many of the trace elements would simply pass through the gastrointestinal tract and not enter the circulatory system via the intestinal lining. Chromium picolinate is a very popular dietary supplement that may reduce body fat, increase lean muscle, and increase insulin sensitivity. Without binding of the trivalent chromium to the picolinic acid, it would not be as readily absorbed, and available to be utilized as an enzyme catalyst. In a similar product, vitamin companies market zinc bound to picolinic acid as a dietary supplement.

Herbicides have been derived from picolinic acid and include clopyralid and picloram. Known also as 3,6-dichloropyridine-2-carboxylic acid, the herbicide clopyralid, labeled for use on weeds and woody plants (including mesquite and thistle), is structured with 6 carbon, 3 hydrogen, 2 chlorine, 1 nitrogen, and 2 oxygen atoms per molecule. Picloram, the organic chemical 4-amino-3,5,6-trichloropyridine-2-carboxylic acid, and known to foresters, range managers, and highway departments as the trade product Tordon, is usually applied to cut tree stumps, as a potassium salt, to prevent resprouting. This herbicide includes an additional chlorine and nitrogen atom in its chemical formula, as compared to clopyralid.

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