Observing Mitosis with Fluorescence Microscopy


The complexity of the relationship between kinetochores and the mitotic spindle reflects the requirement for accurate distribution of the genetic material between dividing cells. The most common error in mitosis is the lack of separation between sister chromatids, resulting in one of the two daughter cells receiving both chromosome copies. This error, which occurs approximately once in 100,000 cell divisions, can take place if chromatids fail to attach to the correct spindle pole or if a pair of chromatids attaches to only one pole. In some cases, the two sister chromatids, although correctly assembled in the mitotic spindle apparatus, simply fail to separate at anaphase.

© 1995-2022 by Michael W. Davidson and The Florida State University. All Rights Reserved. No images, graphics, software, scripts, or applets may be reproduced or used in any manner without permission from the copyright holders. Use of this website means you agree to all of the Legal Terms and Conditions set forth by the owners.
This website is maintained by our
Graphics & Web Programming Team
in collaboration with Optical Microscopy at the
National High Magnetic Field Laboratory.
Last modification: Monday, Dec 08, 2003 at 08:37 AM
Access Count Since December 8, 2003: 15848
Microscopes and digital imaging equipment provided by:
Visit the Olympus Microscopy Resource Center website. Visit the QImaging website.