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Synthetic derivatives of progesterone, often referred to as progestins, are commonly utilized in oral contraceptives, Depo-Provera, and other birth control methods. Progestins, which may help reduce the risk of some cancers, are also frequently prescribed to women suffering from undesirable effects associated with menopause. Yet, administration of synthetic progesterone may itself be problematic at times, occasionally contributing to the development of blood clots, cardiovascular problems, and decreased levels of high-density lipoprotein. To diminish the possibility of such negative side effects, many doctors have begun prescribing progestins in lower dosages.

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