Adenine (Vitamin B-4)

Photograph of Adenine under the microscope

Early studies of chicks and rats that were fed autoclaved cereals without nutritional supplements, indicated that these animals exhibited retarded growth and developed general muscular weakness leading to paralysis. Dr. V. Reader isolated a factor from both yeast and liver that alleviated these symptoms, and he later termed the factor vitamin B-4. This vitamin was determined to be adenine, the purine present as a nucleotide base in both DNA and RNA. However, subsequent investigations indicated that the addition of adenine to the deprived animals' diet did not alleviate the retarded growth and paralysis symptoms. Later, workers found that thiamine (vitamin B-1) cured the symptoms and it is now generally agreed that adenine does not possess any vitamin properties. In fact, the human body has a number of complicated pathways to produce adenine, and this substance is definitely not required as a dietary supplement.

© 1995-2022 by Michael W. Davidson and The Florida State University. All Rights Reserved. No images, graphics, software, scripts, or applets may be reproduced or used in any manner without permission from the copyright holders. Use of this website means you agree to all of the Legal Terms and Conditions set forth by the owners.
This website is maintained by our
Graphics & Web Programming Team
in collaboration with Optical Microscopy at the
National High Magnetic Field Laboratory.
Last modification: Monday, Jul 02, 2018 at 04:23 PM
Access Count Since June 10, 1997: 92240