Glipizide is a synthetic sulfonylurea that is used to treat diabetes mellitus, which is a non-insulin dependent diabetes commonly occurring in adults (and referred to as adult-onset or type II diabetes). Metabolically, glipizide appears to stimulate insulin secretion from beta cells of the pancreatic islet tissue, although the mechanism by which glipizide lowers blood glucose during long-term administration has not been clearly established. Side effects include convulsions and seizures along with fainting or unconsciousness.