Digoxin is a member of a class of drugs called digitalis medicines that are used to improve the strength and efficiency of the heart, leading to better circulation. This helps to reduce swelling in the hands and feet of patients with heart problems. Digoxin is also used after congestive heart failure to reduce the risk of further damage in conjunction with beta-blockers and diuretics. Side effects include skin rash or hives, and in case of overdose, loss of appetite, nausea and vomiting.