Cortisone is a synthetic steroid that is used as a replacement therapy in adrenocortical deficiency states. The powerful steroid is also useful for its potent anti-inflammatory effects in disorders of many organ systems. Cortisone therapy suppresses the output of adrenocorticotropic hormone (ACTH) from the pituitary gland and this in turn suppresses the adrenal cortex. This allows a control of excessive androgen secretion. Corticosteroids are marketed under about 200 trade names. Side effects include increased appetite, indigestion, nervousness, restlessness, and trouble in sleeping.